In view of the intercept problem of a hypersonic gliding target， the intercept window， intercept mode， and damage mode are analyzed， and the conceptual design and trajectory programming requirements of the intercept missile are put forward. The conceptual design is conducted， and an intercept missile scheme with a two-stage booster is designed. Meanwhile， the basic parameters of the propulsion and maneuver systems are determined accordingly. The aerodynamic appearance design and centroid location of the intercept missile are completed. The analysis method and tool of intercept missile trajectory programming are constructed. Based on the design constraints， the intercept missile trajectory programming for the HTV-2 hypersonic gliding target is studied， and the trajectory is solved by particle swarm optimization （PSO）. The results show that the expected maximum intercept speed can be achieved， and the speed constraint index of intercept missile intercepting gliding weapon can be satisfied. In addition， the intercept probability evaluation of the intercept missile is carried out， and it is determined that the hypersonic gliding target can be intercepted from multiple intercept stations in sequence through layered defense.